Endocrine Abstracts

A 43-year-old African lady initially presented in September 2007 with hypothyroidism (fT4 0.6 ng/dl (0.8–2.0) and TSH 110 mU/l (0.3–4.00)). She gave a history of pain in the neck with transient symptoms of thyrotoxicosis. It was felt that she had gone hypothyroid following an episode of subacute thyroiditis and was started on L-thyroxine. Her compliance was questioned as her TSH fluctuated from being high to being suppressed on 25 μg of...

Introduction: Autoimmune polyglandular syndrome (APS) is a group of polyendocrinopathies characterizedby multiple glands insufficiencies associated with other autoimmune diseases resulting from immune mediated destruction. We describe a patient with type 2 APS presenting first with diabetes type 1 followed later by adrenal insufficiency and Hashimoto disease.Case report: A 23-year-old male, known with diabetes type 1, presented with a very low blood pres...

Introduction: Pheochromocytoma, papillary thyroid carcinoma and primary hyperparathyroidism have been reported rarely together. Whether the association is coincidental or results from an underlying unique genetic process is difficult to ascertain.Case description: We report a case of a 59-year-old woman without a family history who had a personal history of multinodular goiter known for the ten last years and pheochromocytoma diagnosed and operated in 20...

Introduction: IgG4-related disease is a newly recognized entity associated with autoimmune conditions involving almost every organ system, characterized by elevated serum IgG4 as well as mass like tissue infiltration by IgG4-positive plasma cells. Pituitary gland can be involved and can presented as hypophysitis.Case description: We report a case of a 56-year-old man, who has been suffering for the nine last years of episodes of fatigue and headaches wit...

A 65-year-old Moroccan man was regularly followed in the outpatient clinic for type 2 diabetes since 2010 and was well controlled with an oral treatment. His past medical history included severe hypertension since 1985. Despite four antihypertensive agents, his blood pressure was not controlled (BP: 220/120 mmHg). A suspicion of renal artery stenosis was excluded by an invasive procedure.He presented an impaired renal function (GFR: 50 ml/min) and his se...

We report on a 50-year-old patient of Moroccan origin, with insulin treated type 2 diabetes known for several years. He presented with a 6 months history of hypoglycemia, hypotension, associated with loss of libido and erectile dysfunction, anorexia, general deterioration and weakness. He had lost 20 kg over a 6-month period. The insulin doses were diminished from 70 to 42 U/day and the antihypertensive treatment was stopped due to repeated episodes of hypotension.<p class...

Introduction: Congenital hypopituitarism may be the result of complications linked with delivery or may sometimes result of insufficient development of the gland in the context of specific genetic abnormalities (PROK2 and PROKR2, LHX4, HESX1, OTX2, GLI2 and SOX3). Interruption or lack of pituitary stalk represents a frequent feature of congenital hypopituitarism.Case description: We present a patient 39-year-old with congenital panhypopituitarism, mental...

Introduction: Patients with clinical clues suggesting the possible presence of secondary hypertension should undergo a more extensive evaluation, because in this case some of these disorders can be cured, leading to partial or complete normalization of the blood pressure.Case description: We report a case of a 43-year-old man, who suffered for years of hypertension despite concurrent use of adequate doses of three antihypertensive agents from different c...

Introduction: Iron-induced hypophosphatemia is a well-known adverse effect in patients receiving parenteral iron supplementation. Initially thought to be transient and mild, it seems that in certain cases, especially in patients who require repeated intravenous iron administrations, it can lead to spectacular symptomatology and serious complications.Case report: A female patient, aged 61 was referred for intense muscle and bone pain, severe impaired mobi...

A 53-year-old lady of African origin presented to the emergency department with a 2 months history of watery diarrhoea associated with anorexia, general deterioration and weakness. She had lost 10 kg over 2 months. There was no history of recent travel abroad. Her past medical history included a cardiac arrest in 2000 (hypertrophic cardiomyopathy) and she had an internal defibrillator implanted for Brugada-like syndrome. She had hypertension since 1999 and it was noted that sh...